Author

Eun Ko

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Open access Aug 2026

Melittin Reprograms Tumor-Associated Macrophages Through CD18-Mediated Immunomodulation.

Tumor-associated macrophages (TAMs), particularly the M2-like subtype, contribute to an immunosuppressive tumor microenvironment and promote tumor progression. Melittin, a natural bioactive peptide derived from bee venom, has been reported to exert anticancer and immunomodulatory effects; however, the cellular targets...

IkJoon Han, Hyunju Lee, Eun Ko et al. · Phytotherapy Research · 0 citations

Open access Jul 2026

CAR19 Tregs treat murine chronic graft-versus-host disease through immune suppression without measurable B cell cytolysis

The findings suggest that CAR19 Tregs represent a promising and safe cGVHD/BOS therapeutic strategy, offering immunosuppressive benefits and improved disease outcomes that may be more limited with CD8+ CAR19 T cell treatment.

Sujeong Jin, Michael C. Zaiken, Cameron McDonald-Hyman et al. · JCI Insight · 0 citations

Jul 2026

Targeting the Transcription Factor Id2 Reveals Novel Regulatory Mechanisms in Chronic Graft-versus-Host Disease 2257336

Genetic Id2 loss uncouples Tfh differentiation from effector activity, positioning Id2 inhibition as a novel therapeutic strategy to selectively disrupt pathogenic Tfh-GCB crosstalk in cGVHD.

Yujie Zhao, Eun Ko, Cameron McDonald-Hyman et al. · Journal of Immunology · 0 citations