Eun-Mi Park

Aβ-induced CaMKII hyperactivation is associated with impaired lysosomal maturation and mitophagy.

Alzheimer's disease (AD) is characterized by amyloid-β (Aβ)-associated synaptic failure, intracellular Ca2+ dysregulation, and progressive impairment of lysosome-dependent clearance pathways. Aβ induces sustained Ca2+ overload, resulting in pathological hyperactivation of CaMKII, which normally participates in the regu...