Redox-dependent structural switching converts Escherichia coli thioredoxin 2 into a molecular chaperone.
Thioredoxins (Trxs) are ubiquitous oxidoreductases that maintain cellular redox homeostasis through thiol-disulfide exchange reactions. Escherichia coli thioredoxin 2 (EcTrx2) possesses a unique N-terminal zinc-binding domain absent from the canonical thioredoxin EcTrx1, but the physiological significance of this domai...