Open access
Jul 2026
Active pH Modulation by Proton Channel‐Peptide Nucleic Acid Complex for Effective siRNA Endosomal Escape
The results indicate that the CPR complex interrupts the endosomal pathway, effectively reducing the colocalization of delivered siRNA with lysosomes and enhancing gene regulation efficiency, suggesting that the CPR nanocarrier design could serve as a versatile platform for targeted RNA delivery.
Seongmin Ga, Nam Hyeong Kim, Si Yeon Ryu et al.
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