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Author

Eunchai Kang

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Open access Aug 2026

Modeling maternal immune activation in 3D ex vivo human fetal brain cerebroids reveals IL-17A-driven disruption of cortical development

Maternal immune activation (MIA) disrupts brain development and increases the risk of neurodevelopmental disorders, yet the mechanisms by which MIA impacts human cortical development remain poorly understood. Here we introduce a three-dimensional ex vivo culture system, termed ‘cerebroids,’ derived from the dorsolatera...

Muhammad Z. K. Assir, Mario Yanakiev, Do Hyeon Gim et al. · 0 citations
Open access Sep 2026

Genotoxic and metabolic stress drive divergent senescence programs in human microglia

Investigating the impact of chronic genotoxic and metabolic stress on senescence-associated phenotypes in the human microglia cell line HMC3 demonstrated that chronic genotoxic and metabolic stress drive distinct yet overlapping senescence programs characterised by morphological changes, mitochondrial remodelling and p...

N. Jose, S. Janssens, Eunchai Kang et al. · 0 citations

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