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Open access Oct 2026

tRNA dosage regulates lineage dependency and resistance in prostate cancer.

Lineage plasticity underlies therapeutic resistance in cancer1,2, yet the translational mechanisms that enable this phenotypic flexibility remain largely unknown. Here using prostate cancer as a model of lineage dependence, we performed unbiased small RNA sequencing and identified tRNA1Arg(UCU) as a regulator of lineag...

Y. Kim, Sonali Arora, D. Young et al. · 0 citations
Open access Sep 2026

Evolution and heterogeneity of lethal metastatic bladder cancer subtypes

It is shown that metastasis-to-metastasis seeding is the dominant pattern of cancer spread and that increased polyclonal migration predicts poor prognosis, and that post-mortem cell-free DNA captures genomic and transcriptional heterogeneity of the subtypes, which provides a potential strategy for noninvasive assessmen...

P. Itagi, Samantha L. Schuster, Sonali Arora et al. · 0 citations

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