Open access
Sep 2026
CD248/Endosialin regulates synovial fibroblast state to control coupling of inflammation and bone damage in murine models of immune-mediated inflammatory arthritis and ageing.
The data suggests that the high levels of CD248 expression seen on synovial fibroblasts provides a protective brake that attenuates bone damage by preventing the polarisation of emergent fibroblasts towards a destructive phenotype.
Samuel Kemble, C. Wehmeyer, James M. Brown et al.
· Arthritis & Rheumatology · 0 citations