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Review Open access Sep 2026

Targeting Stress and the Gut–Brain Axis: Effects of Lifestyle and Psychobiotic Interventions on the Gut Microbiome in Adults—A Systematic Review of Randomized Controlled Trials

Background/Objectives: Stress is increasingly recognized as an important modulator of gut microbiome composition and function through the bidirectional microbiota–gut–brain axis. Dietary, psychobiotic, and other lifestyle-oriented interventions have therefore attracted growing interest as potential strategies for simul...

S. Asimakopoulou, Panagiotis Pipelias, Eva Kassi et al. · 0 citations
Review Open access Aug 2026

Safety and Efficacy of Mesenchymal Stem Cell Therapy in Aging Frailty: A Systematic Review

Aging frailty is a multifactorial geriatric syndrome characterized by reduced physiological reserve across multiple interrelated systems, leading to increased vulnerability to adverse health outcomes. Mesenchymal stem cells (MSCs) have emerged as a potential therapeutic intervention due to their immunomodulatory and re...

Eleni Poutouri, Maria Sotiropoulou, M. Potoupnis et al. · 0 citations
Open access Aug 2026

Empagliflozin inhibits the apoptosis of pancreatic β-cells through amelioration of endoplasmic reticulum (ER) stress

Background Progressive loss of pancreatic β-cell function in type 2 diabetes mellitus (T2DM) is linked to endoplasmic reticulum (ER) stress–induced apoptosis. Sodium-glucose cotransporter-2 inhibitors (SGLT-2i) have glucose-lowering and potential cytoprotective effects. We investigated whether empagliflozin protects β-...

N. Nasiri-Ansari, Manpal S. Randeva, Christina-Maria Flessa et al. · 0 citations

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