Open access
Oct 2026
DND1–NANOS3 shapes the PGC transcriptome via a heptanucleotide sequence in mRNA 3′-UTRs
Summary: Primordial germ cell survival requires joint function of the RNA-binding proteins DND1 and NANOS3; yet, how they collaborate was not established. Here, we discover a paradigm of “two-factor authorization”, where RNA-binding proteins with low (DND1) or no (NANOS3) sequence-specificity jointly repress RNAs via a...
Masataka Suzawa, Chen Qiu, A. Polash et al.
· Molecules and Cells · 0 citations