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F. A. Sumang

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Open access Jul 2026

Genetic dissection of persiathiacin biosynthesis defines hierarchical P450 oxidations and reveals a more potent antitubercular intermediate

The results define the enzymatic logic and temporal organization of persiathiacin biosynthesis, providing a conceptual framework for rational diversification of complex thiopeptide natural products.

F. A. Sumang, Maxwell T. Stevens, W. Britton et al. · bioRxiv · 0 citations