Dietary fatty acids modulate lipolytic enzymes via distinct allosteric and exosite mechanisms: An integrated in vivo and in silico study linking Cafeteria diet-induced obesity to altered lipid metabolism.
The escalating prevalence of obesity necessitates a deeper molecular understanding of how high-fat diets disrupt lipid metabolism. This study aimed to elucidate the potential mechanisms by which dietary fatty acids (FAs) modulate the key lipolytic enzymes, lipoprotein lipase (LPL) and hormone-sensitive lipase (HSL). An...