Introduction Inter-individual variability in adult brain aging can obscure early pathological alterations and is only partly represented by population-average or scalar brain-aging measures. We combined Receptor-Enriched Analysis of functional Connectivity by Targets (REACT) with normative modeling (NM) to derive spati...
Marco Pinamonti, M. Moretto, L. Pieperhoff et al.· bioRxiv· 0 citations
The Amyloid Imaging to Prevent Alzheimer’s Disease Prognostic and Natural History Study (AMYPAD-PNHS) multimodal magnetic resonance imaging (MRI) dataset provides open-access longitudinal MRI data of 2759 cognitively normal or mild cognitive impairment individuals to enhance generalizability and comparability between f...
L. Pieperhoff, M. Tranfa, Prithvi Arunachalam et al.· Scientific Data· 0 citations
The findings highlight the importance of considering cut-point uncertainty and methodological influences when interpreting early-stage amyloidosis and highlight the importance of considering cut-point uncertainty and methodological influences when interpreting early-stage amyloidosis.
W. Coath, A. Bollack, C. Scott et al.· medRxiv· 0 citations
MRI-derived brain-PAD predicts progression to dementia in memory clinic patients with SCD or MCI and provided additional predictive value to visual rating scales in patients with SCD and mild cognitive impairment.
S. de Vries, K. Farkas, Hanneke F. M. Rhodius-Meester et al.· Neurology· 0 citations
Grey matter network topology is altered in Alzheimer’s disease and these alterations are related to cognitive decline, which suggests that preserving cognitive function in the presence of amyloid and prevention of dementia A+ may require therapies that strengthen synapses and targets the innate immune system in additio...
Diederick M. de Leeuw, F. Duits, E. Dicks et al.· Brain Communications· 0 citations
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