F. Bessaguet

Three-dimensional cell culture models in oncology: from tumour spheroids to integrated microphysiological systems.

Traditional two-dimensional (2D) cell cultures fail to capture the structural, mechanical, and biochemical complexity of living tissues, prompting a major paradigm shift toward three-dimensional (3D) cell culture models. 3D systems faithfully replicate in vivo physiological architectures, dynamic cell-to-cell contacts,...