Author

F. Carelli

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Open access Sep 2026

The SynMuvA lin-15A licenses natural transdifferentiation by antagonizing identity safeguarding mechanisms

The mechanisms that restrict or enable latent cellular plasticity have attracted growing interest over the past decade, with important implications for cancer and regenerative therapies. However, the diversity of both pro- and anti-plasticity mechanisms remains incompletely understood. Here, we identify the THAP domain...

Sarah F. S. Becker, Marie-Charlotte Morin, J. Lambert et al. · PLoS Genetics · 0 citations

Open access Sep 2026

Innate immune stress pathway activation underlies heterochromatin dysfunction pathology

Heterochromatin loss disrupts nuclear architecture, gene regulation and repetitive element silencing, and is associated with diverse human diseases. However, mechanisms linking heterochromatin dysfunction to pathological phenotypes remain unclear. Using genetic interaction screening and genomic analyses in C. elegans,...

Roopali Pradhan, Anna F. Townley, A. Protasio et al. · bioRxiv · 0 citations