Author

F. Clanchy

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Review Open access Sep 2026

Epilepsy as a Disorder of Neuroimmune Metabolism: The Kynurenine Pathway as a Link Between Cognitive and Psychiatric Dysfunction

In this narrative review we summarise some of the roles played by glutamate and its receptors in both epilepsy and schizophrenia, before presenting the kynurenine pathway of tryptophan metabolism as a generator of compounds acting at least partly by modulating those receptors. Increasing evidence indicates that epileps...

Trevor W. Stone, F. Clanchy, Richard O. Williams · Biomolecules · 0 citations

Review Open access Aug 2026

GRIA3: proposal for a neuroimmune role linking infection, stress, chronic disorders and the activity of kynurenic acid

The potential for molecular interactions between pDCs and neurons or glia is discussed, with the implications for linking viral infections, pDC activation, and chronic diseases.

Trevor W. Stone, F. Clanchy, Richard O. Williams · Frontiers in Cellular Neuros... · 1 citation