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F. Crea

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Open access Oct 2026

Interleukin-6 predicts cardiovascular events beyond standard modifiable risk factors in individuals without atherosclerotic cardiovascular disease

Current risk stratification algorithms capture high-risk individuals with classical risk factors or established atherosclerotic cardiovascular disease (ASCVD). However, a clinically relevant proportion of individuals without threshold levels of standard modifiable risk factors (SMuRF) – namely hypertension, dysli...

F. Kahles, B. Kurt, K. Schneider et al. · 0 citations
Open access Oct 2026

Longitudinal high-sensitivity C-reactive protein assessment predicts cardiovascular risk in apparently healthy individuals

High-sensitivity C-reactive protein (hsCRP) is the guideline-recommended biomarker for assessment of residual inflammatory risk in atherosclerotic cardiovascular disease (ASCVD). Clinical adoption remains limited, especially in individuals without established ASCVD. This study used longitudinal measurements to ev...

B. Kurt, M. Reugels, K. Schneider et al. · 0 citations
Open access Oct 2026

Prognostic impact of high-sensitivity C-reactive protein trajectories and sustained residual inflammation for prediction of cardiovascular outcomes

Traditional risk factors for atherosclerotic cardiovascular disease (ASCVD) fail to fully reflect the residual risk, driven by chronic low-grade inflammation, observed in many. Generally, high-sensitivity C-reactive protein (hsCRP) concentrations remain stable, but some individuals may experience increases. More...

F. Kahles, M. Reugels, K. Schneider et al. · 0 citations
Review Open access Oct 2026

The Quo Vadis for COVADIS Diagnostic Criteria.

The Coronary Vasomotor Disorders International Study group (COVADIS) developed the diagnostic criteria for vasospastic angina and microvascular angina more than 8 years ago. This article critically reappraises these criteria (Latin: quid fecisti - what has been done) and proposes the strategies for their advancement (L...

John F. Beltrame, Peter Ong, C. Berry et al. · 0 citations
Open access Oct 2026

2026 update on the COVADIS diagnostic criteria of international standardization for microvascular angina.

The updated COVADIS criteria for microvascular angina incorporate new suggestions for endotype definitions based on the invasive assessment of coronary physiology including coronary flow reserve and the index of microvascular resistance during pharmacological stress as well as acetylcholine testing for epicardial and/o...

Peter Ong, P. Camici, John F. Beltrame et al. · 0 citations
Review Open access Aug 2026

Heart Failure and Cancer: Incidence and Mortality Patterns, A Systematic Review and Meta-analysis.

The observed HF-cancer association is influenced by statistical methodology, shared risk factors, differences in surveillance intensity and cancer type, that confound analyses investigating possible causal biological links.

L. Sanasi, A. Iaconelli, Danila Azzolina et al. · 0 citations

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