Author

F. D'Amico

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Review Open access Sep 2026

Advanced Therapies for the Management of Immune Checkpoint Inhibitor-Induced Colitis

Immune checkpoint inhibitors (ICIs), including anti-CTLA-4, anti-PD-1, and anti-PD-L1 agents, have revolutionized cancer therapy by enhancing T-cell–mediated antitumor responses and significantly improving survival across multiple malignancies. Despite these advances, ICIs are associated with immune-related adverse eve...

C. S. Matichecchia, F. Fanizzi, A. Zilli et al. · Cancers · 0 citations

Open access Sep 2026

Real-World Effectiveness and Safety of Upadacitinib in Patients With Crohn's Disease-A Multicentre Prospective Study From the Italian Group for the Study of Inflammatory Bowel Diseases (IG-IBD).

BACKGROUND AND AIMS Upadacitinib is an oral selective JAK1 inhibitor approved for moderate-to-severe Crohn's disease (CD), but real-world prospective multicentre data in advanced therapy-experienced (AT-experienced) patients are limited. The UPGRADE-CD study evaluated its effectiveness and safety. METHODS In this pro...

B. Barberio, F. D'Amico, L. Laterza et al. · Alimentary Pharmacology and... · 0 citations