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Imaging subtypes reveal distinct biological substrates and disability profiles in multiple sclerosis.
Multimodal MRI analysed with SuStaIn identified reproducible subtypes of multiple sclerosis with clinically meaningful differences in phenotype, age at onset, disability, and relapse-independent progression, while cognitive impairment was related to advancing SuStaIn stage within each subtype.
Genome-wide association analyses highlight the neuronal contribution to multiple sclerosis susceptibility
Inhibitory neurons emerged as a key target cell type for MS-associated variants, with seven loci, including STAT3, displaying altered expression only in these cells, suggesting that MS susceptibility may reflect reduced central nervous system resilience to inflammatory challenges.