F. G. Barr

DNA methylation profiling reveals novel rhabdomyosarcoma subsets with distinct histologic, genetic and clinical properties

Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma, and is commonly divided into fusion-positive (FP) (predominantly PAX3::FOXO1 or PAX7::FOXO1) and fusion-negative (FN) subtypes. Based on our earlier finding of different DNA methylation patterns in the FP and FN subtypes, we hypothesized that ther...