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Author

F. Garcia-Gonzalo

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Open access Aug 2026

The dynamics of ciliogenesis in prepubertal mouse meiosis reveals new clues about testis maturation

The dynamics of ciliogenesis during mouse puberty are investigated and it is shown that primary cilia are not an intrinsic feature of spermatocytes during the first wave of meiosis, initiated at 8 days post partum (dpp).

I. Pérez-Moreno, P. López-Jiménez, H. Zapata-Polo et al. · 0 citations
Open access Jul 2026

Selective Brain-Penetrant TTBK1 Inhibitors Modulate TDP-43 Pathology and Rescue Cognitive Deficits in a Mouse Model of TDP-43 Proteinopathy

It is found that these inhibitors reduce TDP-43 phosphorylation levels in neuroblastoma cells and FTD patient-derived models, and restores cognitive deficits, conferred neuroprotection in the frontal cortex, and reduced microglial activation in an FTD-TDP mouse model, supporting its therapeutic potential.

Cecilia Sanchez-Santos, Alberto Jiménez-Amor, Loreto Martínez-González et al. · 0 citations

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