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Author

F. Gardoni

3 papers indexed here

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Open access Oct 2026

D2 dopamine and CB2 cannabinoid receptor cooperation restores striatal LTP in an epilepsy model.

Increasing evidence suggests that subcortical structures contribute to seizure susceptibility and cognitive impairment in several epileptic syndromes. However, research into mechanisms linking neuronal excitability and synaptic dysfunction in epilepsy has mainly focused on the cortex and hippocampus, leaving basal gang...

Miriam Sciaccaluga, Laura Bellingacci, Valentina Imperatore et al. · 0 citations
Review Open access Sep 2026

Therapeutic potential of positive allosteric modulators of AMPA receptors in brain disorders.

α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPA receptors) are ionotropic glutamate receptors that mediate fast excitatory neurotransmission in the central nervous system. By translating chemical signals into rapid electrical depolarization, AMPA receptors, together with NMDA and kainate receptors,...

Alessio Spinola, Maria Italia, F. Gardoni · 0 citations
Open access Sep 2026

Aging is associated with behavioral alterations, lysosomal dysfunction, region-specific inflammation, and glutamatergic synaptic impairments in a Grn knockout mouse model of frontotemporal dementia

Progranulin-related frontotemporal dementia ( GRN -FTD) is an inherited neurodegenerative disorder caused by progranulin (PGRN) deficiency. Although PGRN functions are well characterized and several therapeutic strategies aiming to restore its levels are currently under evaluation, the mechanisms linking PGRN los...

Chiara Bertasini, Maria Italia, Shima Tavakolian Haghighi et al. · 0 citations

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