Increasing evidence suggests that subcortical structures contribute to seizure susceptibility and cognitive impairment in several epileptic syndromes. However, research into mechanisms linking neuronal excitability and synaptic dysfunction in epilepsy has mainly focused on the cortex and hippocampus, leaving basal gang...
Miriam Sciaccaluga, Laura Bellingacci, Valentina Imperatore et al.· Neurobiology of Disease· 0 citations
α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPA receptors) are ionotropic glutamate receptors that mediate fast excitatory neurotransmission in the central nervous system. By translating chemical signals into rapid electrical depolarization, AMPA receptors, together with NMDA and kainate receptors,...
Alessio Spinola, Maria Italia, F. Gardoni· Biomedicine & pharmacotherap...· 0 citations
Progranulin-related frontotemporal dementia (
GRN
-FTD) is an inherited neurodegenerative disorder caused by progranulin (PGRN) deficiency. Although PGRN functions are well characterized and several therapeutic strategies aiming to restore its levels are currently under evaluation, the mechanisms linking PGRN los...
Chiara Bertasini, Maria Italia, Shima Tavakolian Haghighi et al.· Acta Neuropathologica Commun...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.