F. Greten

Oncofetal cell states: cell plasticity drives invasion in premetastatic colorectal tumors

In a recent publication in Nature , Buissant des Amorie et al. provide evidence that an oncofetal cell state which is associated with advanced disease, chemoresistance and metastatic competence emerges already in early-stage T1 colorectal cancer (CRC). Intriguingly, oncofetal cell states at the invasive front are in cl...