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Author

F. Iasevoli

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Open access Sep 2026

681. Transcranial magnetic stimulation reveals altered GABAergic and glutamatergic activity in treatment-resistant schizophrenia

TRS is characterized by the most severe impairments in GABA-A receptor-mediated inhibition and the highest levels of cortical hyperexcitability and inhibitory deficits, alongside shared plasticity impairments across schizophrenia subtypes.

A. Barone, G. Senerchia, G. De Simone et al. · 0 citations
Open access Sep 2026

30. Brain hypometabolism and disorganization domain as putative neuronal correlates in schizophrenia: a comparative head-to-head treatment-resistant vs. treatment-responsive schizophrenia PET study

Abstract Background About a third of schizophrenia patients are refractory to antipsychotics, a condition characterized by poor clinical and functional outcomes known as treatment-resistant schizophrenia (TRS). The disorganization domain may represent the leading factor in categorizing a schizophrenia patient as affect...

M. Ciccarelli, F. Iasevoli, A. Barone et al. · 0 citations
Open access Aug 2026

A Potential Link Between Dyslipidemia and Inflammation in Patients with Schizophrenia: Insights from Sterols and HDL Profile Analysis

The impaired cholesterol metabolism in SCZ patients is associated with a pro-inflammatory state, which is responded to by the anti-inflammatory remodeling of HDL subfractions, and improving intestinal cholesterol absorption and reducing endogenous cholesterol biosynthesis could represent putative therapeutic approaches...

S. Bagnasco, G. De Simone, G. Cernera et al. · 0 citations
Open access Sep 2026

607. When artificial intelligence becomes a rater: detecting formal thought disorders in schizophrenia

Overall agreement is good, supporting its potential role in standardising psychopathology evaluation, and LLM-assisted scoring could enhance reproducibility in psychiatric research and offer scalable support in the clinical assessment of SCZ and TRS.

F. Iannotta, L De Santis, A. Catino et al. · 0 citations
Open access Sep 2026

181. Integrating clinical profiles and microRNAs to uncover molecular mechanisms in treatment-resistant schizophrenia

Findings suggest that increased expression of these miRNAs may enhance gene silencing across synaptic and intracellular signaling cascades, potentially contributing to impaired neuroplasticity and treatment resistance through downregulation of critical neurotransmission-related targets.

L. Vellucci, P. Mirra, A. Nasti et al. · 0 citations
Review Open access Sep 2026

Addressing fusiform gyrus dysfunction in schizophrenia, theory of mind, and implications for antipsychotics' response and resistance: A systematic review and critical appraisal.

The Fusiform Gyrus appears to function as a dynamic, state-sensitive hub underlying perceptual, emotional, and cognitive disturbances in schizophrenia, in line with impaired ToM.

M. Ciccarelli, B. Mazza, A. Nasti et al. · 0 citations
Open access Sep 2026

637. Executive functions in neurodevelopmental disorders: evidence of a cognitive continuum between autism and schizophrenia

The observed pattern of impairment is consistent with that described in chronic schizophrenia and clinical high-risk states for psychosis, confirming that these domains are frequently altered along the continuum of Neurodevelopmental Syndromes (NDS).

C. Ceparano, F. Iannotta, C. Ricci et al. · 0 citations

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