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Author

F. Isa

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2 papers indexed here

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Open access Oct 2026

Maftivimab monotherapy is effective in a non-human primate model of Bundibugyo virus disease

The 2026 outbreak of Bundibugyo ebolavirus (BDBV) in the Democratic Republic of the Congo and Uganda has created an urgent need for treatments for BDBV disease, yet the only FDA-approved ebolavirus therapeutics, the monoclonal antibody (mAb) cocktail Inmazeb® and the mAb Ebanga®, are indicated for Zaire ebolavirus (EBO...

Meike Dittmann, Dylan M. Johnson, M. Rapp et al. · 0 citations
Clinical trial Open access Sep 2026

Pharmacokinetics, Immunogenicity, and Safety of a Modified YTE Antibody in Healthy Adults

Abstract REGN17092, a fully human immunoglobulin (Ig) G1 antibody with M252Y/S254T/T256E (YTE) modification in the Fc portion, was assessed in a first‐in‐human study (ClinicalTrials.gov, NCT05923424). REGN17092 was designed to target the severe acute respiratory coronavirus 2 (SARS‐CoV‐2) S protein. However, due to the...

María Rosario, J. D. de Hoon, F. Isa et al. · 0 citations

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