Understanding of the genetic architecture of AD in the context of its main genetic driver is improved, and APOE-stratified insights may help understand and overcome side effects, inform clinical trial enrollment strategies, and create the scientific basis for targeted, mechanism-driven therapies in neurodegenerative di...
J. Thomassen, H. Leonard, Brittany Ulms et al.· Nature Genetics· 0 citations
Findings indicate that temporo-parietal connectivity is associated with both AD molecular pathology and, for a subset of connections, with memory performance, which may provide a link between synaptic pathology and cognitive outcomes.
Yanin Suksangkharn, B. Schott, P. Zeidman et al.· Alzheimer's Research & Thera...· 0 citations
WMH confluence is introduced as a reproducible, automated, and fine-grained measure of lesion spatial organisation that provides complementary information about morphological WMH severity beyond volume and is an alternative to visual rating scales.
Tatjana Schmidt, Robert Salzmann, M. Montagnese et al.· bioRxiv· 0 citations
BAG is a reliable non-invasive marker of structural brain health sensitive to AD pathology and to modifiable AD risk and supports its relevance for early risk stratification and prevention-oriented research.
E. Kuhn, G. Antopoulos, L. Kleineidam et al.· medRxiv· 0 citations
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