Sep 2026
Ancestral Sequence Reconstruction Synergized with Deep Learning Significantly Enhances the Thermophilicity and Thermostability of the Highly Active Alkaline Protease AprE
Molecular dynamics simulations revealed that AP291 exhibits reduced local structural fluctuations and enhanced conformational stability, clarifying the underlying stability-enhancing mechanism, and AP291 is promising for industrial biocatalysis.
Yi-Min Cai, Ya-Rui Bian, Yu-Ying Chen et al.
· Journal of Agricultural and... · 0 citations