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Author

F. M. Stel

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Open access Jul 2026

Anti-capsid nanobodies function as HIV-1 capsid inhibitors by intracellular capsid degradation.

Antiretroviral therapy (ART) strategies against HIV-1 have been successful in suppressing HIV-1 replication and preventing disease progression. However, drug-resistance development, side-effects and life-long adherence of current drugs have driven the development of novel inhibitors against HIV-1. Inhibition of capsid...

F. M. Stel, Charlotte E J Verkuijlen, E. Zijlstra-Willems et al. · 1 citation
Open access Aug 2026

Capsid-Targeting Biologic Achieves Broad HIV-1 Neutralization with a High Barrier to Resistance

The results demonstrate the broad neutralization potential of anti-capsid biologics with a high barrier to resistance, making capsid-targeting inhibitors important for novel antiretroviral drug strategies worldwide.

F. M. Stel, E. Zijlstra-Willems, A. van Nuenen et al. · 0 citations

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