Author

F. Marchesi

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Open access Sep 2026

Characterization of FLT3-ITD-mutated leukemic stem cells: functional and clinical insights

Despite treatment advances, relapsed/refractory FLT3 -ITD-mutated acute myeloid leukemia ( FLT3 -ITD mut AML) remains an unmet medical need. We previously identified a CD34/CD123/CD25/CD99+ leukemic progenitor cell (LPC) population that persists after induction treatment and drives disease recurrence in FLT3...

S. Travaglini, T. Ottone, S. Antonelli et al. · Cell Death Discovery · 0 citations

Open access Aug 2026

Efficacy and Potential Limitation of the Menin Inhibitor Revumenib Outside Clinical Trials: Extramedullary Response with Central Nervous System Escape in a Case of KMT2A-Rearranged Acute Myeloid Leukemia

Acute myeloid leukemia (AML) harboring KMT2A rearrangements (KMT2A-r) accounts for approximately 5–10% of newly diagnosed cases and represents a high-risk AML subtype associated with poor clinical outcomes despite intensive treatment strategies, including allogeneic hematopoietic stem cell transplantation (HSCT). KMT2A...

Martina Canichella, C. Papayannidis, Mariagiovanna Cefalo et al. · TARGETS · 0 citations