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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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F. Mardakheh

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Open access Sep 2026

LARP1-DM15/Sgt is a reader for cap-adjacent 2’-O-ribose methylation in TOP ribosomal protein mRNAs required for localization to synapses

The most prominent mRNA modification in animals and many of their parasites is 2’-O-ribose methylation of cap-adjacent nucleotides (cOMe) introduced by cap-methyl transferases (CMTrs). How these modifications impact on gene expression and are decoded by reader proteins, however, remains uncertain. Through analysis of t...

Yuan W. Tian, Yavor Hadzhiev, G. Abis et al. · 0 citations

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