Author

F. Massaoudi

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Open access Oct 2026

Mitochondria transfer via tunneling nanotubes drives macrophage immunosuppression and metabolic reprogramming in pediatric AML.

It is demonstrated that immunosuppressive macrophages dominate the AML microenvironment and support growth of RUNX1::RUNX1T1 and KMT2A-rearranged leukemic blasts and suggested that targeting AML-macrophage interactions could enhance the efficacy of T cell-based immunotherapies.

A. Perzolli, F. Massaoudi, A. V. van Oort et al. · Leukemia · 0 citations