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Author

F. Mentch

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Open access Aug 2026

Shared genetic architecture and therapeutic targets across paediatric immune-mediated diseases.

Paediatric IMIDs shared broad polygenic architecture with adult IMIDs, whereas top-ranked genes converged strongly with adult rheumatic diseases, providing a genomic framework for paediatric precision medicine, guiding classification, risk prediction, and therapeutic development.

Jin Li, Hui-Qi Qu, Michael E. March et al. · 0 citations
Open access Jul 2026

Drug repurposing opportunities across 92 CNS-related conditions using deep learning and whole-genome sequencing

Variant-class-resolved WGS pathway prioritization coupled to curated pharmacology enables scalable cross-diagnosis repurposing using existing drugs, recovering clinically explored strategies and generating genetically supported hypotheses for biomarker-guided validation.

Yi-Chuan Liu, Hui-Qi Qu, F. Mentch et al. · 0 citations

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