Author

F. Meyer-Almes

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Sep 2026

Discovery of cyanocarbonimidodithioates as novel non-hydroxamate zinc-binding groups for selective HDAC8 inhibition: Design, synthesis, biological evaluation, anticancer activity, and in silico studies.

Sai Chaitanya Kosana, Hrushikesh S. Chaudhari, Ashna Fathima et al. · Bioorganic chemistry (Print) · 0 citations

Open access Aug 2026

Exploration of non-hydroxamate based quinoline analogues as HDAC8 inhibitors

Histone deacetylase 8 (HDAC8) has emerged as a promising therapeutic target due to its role in epigenetic regulation. In this study, novel non-hydroxamate-based quinoline analogues were designed and explored as HDAC8-selective inhibitors that exhibit nanomolar HDAC8 enzymatic inhibition. Notably, compounds BHC-10 and B...

N. V. M. Rao Bandaru, Vandana Joshi, M. Schweipert et al. · RSC Advances · 0 citations