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Author

F. Petrelli

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Review Open access Sep 2026

Early-onset adenocarcinomas of the distal esophagus, gastroesophageal junction, and stomach: a systematic review and meta-analysis of 45 studies

Background The incidence of adenocarcinomas of the distal esophagus, gastroesophageal junction (GEJ), and stomach diagnosed before age 50 years is increasing and early-onset disease may have a distinct phenotype. A comprehensive synthesis of clinicopathological and molecular differences between early-onset and average-...

F. Petrelli, L. Dottorini, S. Cherri et al. · 0 citations
Review Oct 2026

Targeting RAS in pancreatic cancer.

Pancreatic ductal adenocarcinoma (PDAC) remains among the most lethal malignancies, and activating KRAS mutations occur in more than 90% of tumors. Direct RAS targeting has moved from proof of concept to randomized clinical benefit: in previously treated metastatic PDAC, daraxonrasib improved median overall survival, p...

F. Petrelli, L. Dottorini, A. Zaniboni · 0 citations
Review Open access Aug 2026

Management of Advanced Solid Tumors Recurring After Adjuvant Immune Checkpoint Inhibitors: A Structured Narrative Review

Simple Summary When cancer returns after immune checkpoint inhibitor treatment given around curative surgery, clinicians often have little direct evidence to guide the next therapy. This review examines melanoma, non-small-cell lung cancer, renal cell carcinoma, urothelial carcinoma, and triple-negative breast cancer....

F. Petrelli, L. Dottorini, A. Ghidini et al. · 0 citations
Review Aug 2026

Latitude, Seasonality, and Circadian Determinants of Outcomes of Systemic Cancer Therapy: Evidence from Chemotherapy, Immunotherapy, and Chemo-Immunotherapy Combinations. A Systematic Review.

Time-of-day of treatment, seasonality, latitude-related sunlight exposure, vitamin D status, and circadian rhythm integrity are potentially relevant determinants of systemic therapy outcomes.

A. Ghidini, L. Roncari, R. Bukovec et al. · 0 citations
Review Sep 2026

Central nervous system and cancer: mechanistic insights and therapeutic opportunities CNS and cancer: a review

This review synthesizes how nerves and brain activity directly influence tumour growth across multiple diseases—including gliomas, small cell lung cancer, breast cancer, pancreatic cancer, and prostate cancer—and how these neural signals converge with metabolic and drug-resistance pathways that limit the efficacy of co...

F. Petrelli, A. Callea, A. Ghidini et al. · 0 citations
Review Jul 2026

Next-Generation Checkpoint Combinations: Optimizing PD-(L)1–Based Therapy Across the Advanced, Adjuvant, and Neoadjuvant Settings

Within RCC, bladder cancer, and NSCLC, next-generation PD-(L)1 combinations are reshaping treatment across all disease stages, and the magnitude of benefit, the relevant biomarkers, and the toxicity trade-offs differ substantially by tumor type and by setting.

F. Petrelli, Lara Colombo Zefinetti, A. D'Alessio et al. · 0 citations

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