DNA methylation provides a stable record of cellular identity, capturing epigenetic programs that distinguish specialized cell states despite a shared genome. Because malignant transformation and tumour progression are accompanied by extensive epigenetic remodeling, we hypothesized that the methylome of melanocytic les...
J. Winterstein, L. Heinlein, G. Raddatz et al.· 0 citations
IDH1-mutant grade 4 astrocytomas exhibit pronounced interactions with the tumor microenvironment that critically influence tumor progression. Tumor-associated microglia/macrophages (TAMs) are key mediators of these interactions, yet the molecular mechanisms governing tumor-TAM crosstalk remain incompletely unders...
Nathalie Große, F. Sahm, C. Herold-Mende et al.· Neuro-Oncology· 0 citations
DNA methylation–based classification has transformed the diagnosis of central nervous system (CNS) tumours. However, methylation profiling alone is insufficient for definitive diagnosis and must be integrated with genomic alterations such as single nucleotide variants, structural variants, and gene fusions. Molec...
S. Deacon, Inswasti Cahyani, Nadine Holmes et al.· Neuro-Oncology· 0 citations
Pediatric solid high-risk malignancies mostly lack established molecular biomarkers for early detection, minimal residual disease assessment, or treatment monitoring. Challenges include small patient numbers, limited sample volumes, low tumor mutational burden, and few recurrent alterations. Within the multicenter pedi...
K. Maass, P. Puranachot, S. Volz et al.· Genome Medicine· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
