Schaftoside from galgeuntang as a multi-target class I histone deacetylase inhibitor: Integrated molecular docking, dynamics, and systems pharmacology analysis.
Histone deacetylases (HDACs) are enzymes that remove acetyl groups from lysine residues of histone proteins, playing a critical role in gene expression regulation. Particularly, Class I HDACs (HDAC1, HDAC2, and HDAC8) are implicated in cancer development and have attracted significant interest as therapeutic targets. H...