From Enzyme to Parasite: Enzymatic and Phenotypic-Guided Evaluation of Repurposed Inhibitors against Schistosoma mansoni cathepsin D1 ( Sm CD1)
Schistosomiasis remains a major public health concern in endemic regions, with treatment relying almost exclusively on praziquantel (PZQ). Although vital, PZQ shows limited activity against immature parasites and raises potential resistance concerns. In this context, Schistosoma mansoni cathepsin D1 (SmCD1), an essen...