F. Takahashi-Yanaga

The MAPK pathway as a pharmacological target to reprogram cancer-associated fibroblasts and disrupt the stromal shield.

The tumor microenvironment is a complex and dynamic ecosystem composed of a heterogeneous population of non-malignant cells, an extracellular matrix, and diverse soluble factors. Collectively, these elements orchestrate a pro-tumorigenic niche that supports tumor initiation, progression, and metastasis. Within this eco...