F. V. van Kemenade

Distinct epigenetic signatures define HPV-positive and HPV-negative tonsil carcinomas.

INTRODUCTION Epigenetic modifications, particularly DNA methylation, play a key role in oropharyngeal squamous cell carcinoma (OPSCC). This is the first study to apply genome-wide methylated DNA sequencing (MeD-seq) to identify differentially methylated regions (DMRs) in OPSCC. By comparing HPV-positive and HPV-negativ...