Author

F. V. van Werven

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Open access Aug 2026

Cellular context restricts a promiscuous m6A reader IDR to a single functional effector interface for mRNA decay

On endogenous m6A-modified transcripts during meiosis, the promiscuous Pho92 IDR is restricted to a single functional interface, revealing unappreciated specificity in m6A-directed mRNA decay.

W. Chan, Enkai Jin, H. Cross et al. · bioRxiv · 1 citation

Open access Aug 2026

RNA terminal uridylyl transferases are druggable vulnerabilities in AML but are dispensable for normal hematopoiesis

Together, these findings identify TUT4/7 as druggable targets, whose inactivation suppresses AML while sparing normal hematopoiesis, and represents a promising therapeutic strategy in combination with venetoclax.

Christopher Mapperley, Elise Georges, A. Azar et al. · Science Advances · 0 citations