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Open access Sep 2026

A Clonidine-Associated α-Adrenergic Hypothesis in Sleep Bruxism Pharmacotherapy: An Evidence-Anchored Target Analysis.

BACKGROUND Sleep bruxism (SB) is a centrally regulated, arousal-related motor behaviour, but no pharmacotherapy has demonstrated reliable clinical efficacy. This study aimed to identify pathway-level signals most consistently supported by current polysomnography (PSG)-based pharmacotherapy evidence for SB. METHODS We...

De-Shui Li, Shan-Liang Sun, Hui Chen et al. · 0 citations
Open access Aug 2026

Bioadhesive‐Integrated 3D‐Printed Multilayer Scaffolds Secure a Mechanically‐Stable Osteoimmune Niche for Enhanced Bone Augmentation

ABSTRACT Early mechanical stabilization within the osteogenic niche is a key regulator of bone regeneration fate, and maintaining stability in material‐driven repair remains a clinical challenge in dynamic, non‐retentive, and anatomically complex bone defects, where implant materials are difficult to achieve stable fix...

De-Lu Zhao, Qiu-Yi Li, Lingyun Wang et al. · 0 citations
Review Open access Sep 2026

3D printing in orthodontics: current clinical applications, challenges, and future directions

Three-dimensional (3D) printing has become an important component of digital orthodontics and has expanded its role from model fabrication to the production of a wide range of customized appliances. This review summarizes the current clinical applications of 3D printing in orthodontics, including diagnostic models,...

Feng Qiu, Jing-Yi Yu, Meng-Fei Xu et al. · 1 citation

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