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Fabian M. Kulier

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Open access Oct 2026

Dual-Function Cosubstrates Enable Threonine Dehydrogenase-Driven Chemoenzymatic Pyrrole Synthesis.

Preparative biocatalytic synthesis of substituted pyrroles remains challenging despite recent advances in enzymatic α-aminoketone generation. In this study, we report a concurrent chemoenzymatic cascade to disubstituted pyrroles based on threonine dehydrogenase (ThrDH)-catalyzed generation of aminoacetone from l-threon...

Valentina Jurkaš, Fabian M. Kulier, Jorge González-Rodríguez et al. · 0 citations

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