Author

Fabiana da Silva Alcântara

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Open access Oct 2026

eNOS uncoupling drives oxidative stress and arrhythmogenic vulnerability in experimental hypothyroidism

Aims Cardiac arrhythmias are a major cause of morbidity and sudden cardiac death worldwide, and hypothyroidism has emerged as an important risk factor. Among the mechanisms involved in cardiac electrical stability, nitric oxide (NO) signaling, particularly via endothelial nitric oxide synthase (eNOS), plays a critical...

D. S. Souza, L. Marques, A. Durço et al. · Redox Biology · 0 citations

Review Open access Oct 2026

The Pesticide Pyrethroid Metabolite 3-Phenoxybenzoic Acid (3-PBA) Impairs Human Cardiac Nav1.5 and Action Potential Depolarization

This study demonstrates that 3-PBA interacts with human cardiac Nav1.5 expressed in Human Embryonic Kidney (HEK293) cells, and significantly increases INa-L in a concentration-dependent manner with an EC50 of 51.3 ± 5.1 µM, and suggests that its cardiotoxic potential may become clinically relevant under conditions of h...

Michael Ramon de Lima Conceição, L. Marques, Fabiana da Silva Alcântara et al. · Cardiovascular Toxicology · 0 citations