CD4+ T Cell Subsets in CNS Disorders: Pathogenic Roles, Immune Dysregulation, and Therapeutic Perspectives.
The central nervous system (CNS), previously considered immune-isolated due to the blood-brain barrier (BBB) and absence of lymphatic drainage, is now understood as a dynamic interface with the peripheral immune system. CNS neurons and glia actively modulate immune responses, and circulating T cells survey and sometime...