Functional annotation of PBK missense SNPs and dysregulation in multiple myeloma: A bioinformatics approach integrating identification of natural inhibitors
T-LAK cell-originated protein kinase (PBK/TOPK) is a serine/threonine kinase that is essential for DNA damage repair, cell division, mitosis, and tumor growth. Deleterious missense single nucleotide polymorphisms (nsSNPs) may alter the biological activity of PBK and structural stability, thus contributing to cancer pro...