Author

Fan-Dong Yang

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Open access Aug 2026

Metformin improves chronic rhinosinusitis with depressive-like behavior in mice by targeting TCF4 to inhibit the TLR4/NF-κB pathway

This study comprehensively links TCF4 to neuroinflammation in CRSDB, and identified TCF4 as a direct target of metformin, through which it inhibits the TLR4/NF-κB pathway and subsequent microglial activation.

Bingxi Yu, Fan-Dong Yang, Jingwen Tian et al. · Scientific Reports · 0 citations