Recently, inhibiting thioredoxin-interacting protein (TXNIP), a protein that plays critical roles in glucose metabolism, has emerged as a promising therapeutic strategy for diabetes. Through screening a compound library using a TXNIP reporter system, we identified an orally bioavailable small molecule (SKL-1223) that e...
Zhi-Kuan Luo, Jun Han, Tao Zhong et al.· Journal of Medicinal Chemist...· 0 citations
NF-κB must remain bound to chromatin long enough to activate innate immune genes, but what stabilizes this transcriptionally productive state is unknown. Here, we identify the Integrator complex as an essential determinant of NF-κB chromatin residence in mouse and human cells. Integrator associated with NF-κB and co-oc...
P. Cingaram, Jing-Yin Yue, Fan Liu et al.· bioRxiv· 0 citations
This work shows that RNAPII is degraded during many types of cellular stresses, and redistribution is vital for cell survival, as degradation blockage resulted in the loss of RNAPII from low GC promoters and compromised stress response from disrupted cell adhesion to increased apoptosis.
Hansong Qi, Kang-Hsin Chen, Ning Liu et al.· Science Advances· 0 citations
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