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Open access Aug 2026

Proximal Proteomics Reveals Potential Regulators of Programmed Death-Ligand 1 in Human Cancer

Programmed death-ligand 1 (PD-L1) is a key mediator of tumor immune evasion, but the protein networks governing its post-translational regulation remain incompletely understood. Here, we used PhastID-based proximity labeling to map the PD-L1 proximal proteome and integrated these data with pan-cancer proteomics and imm...

Fujin Shi, Danya Liu, Yaxiong Liu et al. · 0 citations
Open access Aug 2026

Spatial mapping of RNA turnover kinetics in the mouse brain.

Gene regulation requires coordinated control of RNA synthesis and degradation, yet measuring RNA turnover across intact tissues remains challenging. Here we present spatial NT-seq, a method that combines transgenesis-free metabolic RNA labeling with in situ chemical recoding on spatial transcriptomics platforms to co-m...

Q. Qiu, Hongjie Zhang, Zi-Jie Xia et al. · 0 citations

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