Peripheral endotoxemia is associated with microglial activation, neuronal apoptosis, and amyloid precursor protein accumulation.
Chronic microglial activation and the resulting neuroinflammatory cascade drive Alzheimer's disease (AD) progression. Systemic lipopolysaccharide (LPS) triggers robust microglial responses and is linked to neurodegenerative disorders, yet the full spectrum of neuroinflammatory and neuronal changes associated with chron...