Association of methylenetetrahydrofolate reductase C677T polymorphism with lacunar infarction: A systematic review and meta-analysis
Background: The association between the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and lacunar infarction (LI) remains inconclusive. Methods: The literature retrieval encompassed PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure, and Wanfang (inception – March 2026). Case-con...