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Review Open access Sep 2026

Targeting subchondral osteoporosis in osteoarthritis: biomechanical crosstalk and the therapeutic rationale for inflammatory microenvironment remodeling

Current osteoarthritis (OA) management remains largely symptom-directed, while the contribution of osteoporosis (OP)-related and OA-associated subchondral remodeling to disease heterogeneity remains uncertain. This review integrates macroscopic load redistribution and lower-limb malalignment with local osteoimmune proc...

Ming-Li Han, Long-Fei Han, Su-Yan Zhang et al. · 0 citations
Open access Aug 2026

Preoperative CT-derived thigh muscle quality as a predictor of postoperative outcomes after total knee arthroplasty in patients with hemophilia

Background Postoperative recovery after total knee arthroplasty (TKA) for haemophilic arthropathy varies substantially, and objective imaging markers for preoperative risk stratification remain limited. This study investigated whether computed tomography (CT)-derived thigh muscle quality and tissue composition are asso...

Rui Feng, Jia-qi Yang, Yang Liu et al. · 0 citations

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